Join us for an exciting PhD project within the DFG-funded research unit FOR2743 “Mechanical Stress Protection”! Mechanical stress affects almost every cell in the human body, but the molecular mechanisms allowing cells to respond and adapt to these forces are still incompletely understood. In previous work, our team at the Central Institute for Engineering, Electronics and Analytics (ZEA-3) together with the Institute of Biological Information Processing (IBI-2), have established in vitro assays for proteome analysis after controlled application of mechanical stress. This allowed us to identified autophagy as a major factor in cellular adaptation. We now strive to obtain a systems-level understanding of protein degradation and autophagy under mechanical stress, both in vitro in cell-based systems as well as in vivo in tissues of selected models such as mice with genetically impaired capacity for mechanoadaptation. Further information on the research unit is available at https://www.for2743.uni-bonn.de/info
We are looking to recruit a
PhD Position – Proteome dynamics under mechanical stress
- Proteome analysis of cells, tissues, and enriched subcellular fractionations, including sample preparation, data acquisition and bioinformatics analysis
- Adapt and develop new protocols for the characterization of autophagy targets
- Perform cell biological experiments, including cell culture and application of mechanical stress
- Contribute to mass spectrometry instrument operation and maintenance
- Present results at national and international conferences and publish in peer reviewed journals
- Contribute to supervision of internship and BSc/MSc thesis students
- Master´s degree in analytical chemistry, biochemistry, cell biology or a related field with a good final grade (equivalent to grade 2.0 or better in the German grade system)
- Experience in cell biology and biochemistry
- Curiosity and motivation paired with an aptitude for reliable self-organized work
- Strong communication skills in English (fluent)
- Previous experience in proteomics, mass spectrometry, and large-scale data analysis is strongly preferred
We work on the very latest issues that impact our society and are offering you the chance to actively help in shaping the change! We offer ideal conditions for you to complete your doctoral degree:
- A highly motivated working group as well as an international and interdisciplinary working environment at one of Europe’s largest research establishments
- Participation in the interactive multidisciplinary research unit FOR 2743, with optimal conditions for collaboration and training
- Further development of your personal strengths, e.g. through an extensive range of training courses; a structured program of continuing education and networking opportunities specifically for doctoral researchers via JuDocS, the Jülich Center for Doctoral Researchers and Supervisors: https://www.fz-juelich.de/judocs
- Excellent experimental facilities at ZEA-3 (Analytics) and IBI-2 (Biomechanics)
- Supportive supervision and a highly collaborative and interdisciplinary team
- A large research campus with green spaces, offering the best possible means for networking with colleagues and pursuing sports alongside work
- Targeted services for international employees, e.g. through our International Advisory Service
The position is initially for a fixed term of 3 years and available from Sept 1st, 2021. Pay in line with 65% of pay group 13 of the Collective Agreement for the Public Service (TVöD-Bund) and additionally 60 % of a monthly salary as special payment („Christmas bonus“). Further information on doctoral degrees at Forschungszentrum Jülich including our other locations is available at: www.fz-juelich.de/gp/Careers_Docs
Forschungszentrum Jülich promotes equal opportunities and diversity in its employment relations.
We also welcome applications from disabled persons.
We look forward to receiving your application until 01.09.2021 via our
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