Doctoral student in Biomarkers in ovarian cancer
University of Gothenburg
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Project title: Identification of novel prognostic and predictive biomarkers in ovarian cancer
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Despite favorable 5-year survival rates, approximately 30% of early-stage ovarian cancer patients develop recurrence within five years after initial diagnosis. Additionally, there is currently no effective way to distinguish patients with varying clinical outcomes or those that may benefit from adjuvant treatment. We hypothesize that for most patients, the genetic makeup of the primary tumor can predict aggressive tumor features that determine whether relapse may occur. To test this hypothesis, we studied the genetic signatures from an ovarian cancer cohort and identified several potential novel biomarkers that can predict aggressive tumor behavior. Our specific objectives are to 1) determine whether altered protein levels of the candidate biomarkers are associated with ovarian cancer-specific survival and different ovarian cancer histotypes, and 2) define the tumorigenic and therapeutic potential of candidate biomarkers using patient-derived cancer cells and mouse models. We will investigate whether specific chemotherapeutic drugs can be used to treat patient-derived xenografts and corresponding organoids from ovarian tumors expressing the candidate biomarkers. This will shed light on the role of these biomarkers in tumor behavior and may provide valuable information for treatment strategies. Importantly, our work will allow future improvement of the decision-making process for ovarian cancer treatment.
Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.
To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.
A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad
A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies
In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
– specific knowledge and skills within the subject area and related research fields
– experience of scientific theory and relevant research methodology
– scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.
Location: Sahlgrenska Academy, Institute of Clinical Sciences, Department of Oncology. Extent: 100%. First day of employment: as agreed.
Salaries for doctoral students are regulated in a local agreement at the University.
For further information regarding the position
For more information about the project please contact the principal supervisor,
Khalil Helou, Associate Professor, Institute of Clinical Sciences,
phone: +46 (0)31 786 6746, e-mail: email@example.com
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You must include the following, in pdf format
- Personal letter
- Diploma and transcripts showing that you meet with the general entry requirement
- Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier.
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
For information on what you need to submit in order to fulfill the English language requirement see https://www.universityadmissions.se/en/entry-requirements/english-language-requirements/
Closing date: 2021-10-20
The University of Gothenburg promotes equal opportunities, equality and diversity.
Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.
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